Ellen D. Zhong

Princeton University

Ellen D. Zhong has made significant contributions to the fields of structural biology and cryo-electron microscopy through their research in revealing biomolecular structure and motion. Recent studies have advanced the technique of ab initio reconstruction, enabling the determination of complex protein structures with unprecedented accuracy. Zhong's work has also focused on analyzing dynamic protein interactions, including substrate polyubiquitination and conformational states of microtubule nucleators. Their novel approaches, such as CryoDRGN, have improved heterogeneous reconstruction methods, allowing for a deeper understanding of biomolecular ensembles and their dynamics. These advancements hold great promise for advancing our knowledge of cellular processes and potential therapeutic applications.