Tuomas P. J. Knowles

University of Cambridge

Tuomas P. J. Knowles has made significant contributions to the understanding of amyloid fibrils and their role in neurodegenerative diseases. Research on shear forces in primary and secondary nucleation revealed crucial mechanisms in amyloid formation, while biomolecular condensates with complex architectures were characterized by interphase electric potentials. These findings have implications for the development of novel therapeutic strategies targeting Alzheimer's disease. Additionally, studies on electrolyte-gated transistors, albumin-drug conjugate processing, and peptide self-assembly have demonstrated the potential of biomolecular condensates in materials science and biophysics.