Christine M. O’Keefe

Johns Hopkins University

Christine M. O'Keefe has made significant contributions to the development of low-cost, high-throughput digital microfluidic analysis technologies for enhanced detection and profiling of early-stage lung cancer through DNA methylation heterogeneity. Their work encompasses multiplex digital PCR, rapid inhibition concentration analysis, and nanoarray digital polymerase chain reaction, enabling broad bacteria identification and molecular heterogeneity profiling. These advancements have far-reaching implications for population data science, health research, and service science, with applications in personalized medicine, infectious disease surveillance, and biomedical research. The researcher's work promotes efficient sample preparation, analysis, and data integration, advancing our understanding of complex biological systems and informing evidence-based decision-making.