46.4
Caslyn Whitesell
Purdue University West Lafayette
Caslyn Whitesell's research has significantly advanced understanding of the E2 domain of amyloid precursor protein (APP), a critical component in Alzheimer's disease pathology. Through recent studies, Whitesell elucidated the ferric oxidizing ferroxidase activity and superoxide and peroxynitrite scavenging capabilities of this domain. These findings provide valuable insights into the molecular mechanisms underlying APP-mediated neurodegeneration. The results have important implications for the development of therapeutic strategies targeting APP-related diseases, highlighting the potential for E2 domain modulation to mitigate oxidative stress and inflammation in neurodegenerative disorders. This research contributes significantly to our understanding of Alzheimer's disease biology.