59.6
Felix Nicolaus
Stockholm University
Felix Nicolaus' research has significantly advanced our understanding of cotranslational folding and assembly of membrane proteins, shedding light on the intricate mechanisms governing the integration of transmembrane helices into the inner membrane of E. coli. Recent studies have elucidated the critical roles of charged and hydrophobic residues in modulating the timing of membrane insertion, highlighting their impact on protein function and cellular behavior. Additionally, Nicolaus' work has elucidated the cotranslational folding of human growth hormone in both in vitro and in vivo systems, providing valuable insights into the molecular mechanisms underlying this process.