74.5
Isabelle Lihrmann
Différenciation et Communication Neuronale et Neuroendocrine, Inserm, Université de Rouen Normandie, Normandie Université, Institute for Research and Innovation in Biomedicine
Isabelle Lihrmann's research has significantly advanced our understanding of selenoproteins, proteins that require selenium for their function, and their roles in various physiological processes. Studies have shown that selenoprotein T plays a crucial role in maintaining endoplasmic reticulum homeostasis, protecting against neurodegenerative diseases such as Parkinson's, and regulating gene expression. Additionally, research on pituitary adenylate cyclase-activating polypeptide (PACAP) has revealed its importance in promoting neuronal survival and neuritogenesis, while also highlighting the evolutionary history of related peptide families. These findings have far-reaching implications for our understanding of brain physiology, neuroprotection, and the development of new therapeutic strategies for various diseases.