56.6
Mark Schreuder
University of Sydney, Centenary Institute
Mark Schreuder's research has significantly advanced our understanding of cell death, coagulation, and lipid metabolism in the context of cancer. In preclinical assessments, a novel Hsp90 ligand, [68Ga]Ga-CDI, was found to be effective for positron emission tomography (PET) imaging of cell death. Additionally, studies on blood coagulation factor Va revealed key residues and regions critical for prothrombinase assembly and prothrombin binding. Schreuder's work also highlighted the role of extracellular fatty acids in lipid synthesis in prostate cancer cells, while elevated coagulation factors were shown to impact thrombin generation thresholds. Furthermore, research on engineered Factor Xa variants demonstrated that these proteins retain procoagulant activity independent of direct inhibitors. Notably, targeting ASC-T2 mediated glutamine uptake was found to inhibit prostate cancer growth and tumour development, highlighting potential therapeutic strategies for this devastating disease.