80.2
Nico J. Meeuwenoord
Leiden University
Nico J. Meeuwenoord's research contributes significantly to the fields of vaccine development and synthetic biology. Intradermal vaccination approaches utilizing HPV-16 e6 peptides conjugated to Toll-like receptor 2 ligands show promise in stimulating potent T-cell immunogenicity in patients with high-risk lesions. Additionally, advances in peptide synthesis enable the creation of novel, self-adjuvanting cancer vaccines that target specific immune cells and tumor antigens. The development of tools for studying adp-ribosylation and amyloid oligomerization also sheds light on the molecular mechanisms underlying various diseases. Furthermore, breakthroughs in the synthesis of teichoic acid fragments, glycopeptide mimics, and methylene bisphosphonates expand the repertoire of synthetic biology applications. These innovations hold significant potential for the development of effective cancer therapies and treatments.