56.4
Rie Takashima
Kyoto Pharmaceutical University
Rie Takashima has made significant contributions to various fields, focusing on targeted drug delivery and gene expression. Research highlights l-serine-modified poly-l-lysine as a biodegradable carrier for radionuclide therapy in renal cell carcinoma, demonstrating potential for efficient treatment. Vitamin K-mediated PXR activation influences drug-metabolizing genes in human intestinal carcinoma cells. Additionally, s-nitrosylated dendrimer and l-cysteine/l-serine modified dendrimers have been explored as kidney-targeting NO donors and ROS scavengers to prevent renal ischemia/reperfusion injury. Furthermore, effects of vitamin K2 on bile acid synthesis and glucose homeostasis in mice with humanized PXR have been investigated, shedding light on the regulation of genes involved in these processes.