56.4

S Staddon

University College London, Great Ormond Street Hospital

Researcher S Staddon has made significant contributions to various fields of study. In the area of immunotherapy, a phase 1 clinical trial demonstrated the safety and potential efficacy of CRISPR-engineered CAR19 universal T cells for treating refractory B cell leukemia in children. Additionally, proteomic analysis revealed the anti-inflammatory properties of minocycline, while functional and biophysical studies elucidated the C-terminus of the CGRP-receptor. Staddon's work also sheds light on the genetic underpinnings of psychiatric disorders, with findings linking the dysbindin gene to bipolar affective disorder and the high-activity val allele of the catechol-O-methyltransferase gene to cognitive deterioration in psychosis. Furthermore, research associated dopamine D3 receptor gene polymorphisms with schizophrenia in an isolated population, highlighting the complexity of this complex disorder.

Dopamine Dysfunction
Commercial signal 56.0
Scientific signal 59.4
Social signal 56.2
Papers 6
1 Patent-to-paper cites
275 Paper cites

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