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S Staddon
University College London, Great Ormond Street Hospital
Researcher S Staddon has made significant contributions to various fields of study. In the area of immunotherapy, a phase 1 clinical trial demonstrated the safety and potential efficacy of CRISPR-engineered CAR19 universal T cells for treating refractory B cell leukemia in children. Additionally, proteomic analysis revealed the anti-inflammatory properties of minocycline, while functional and biophysical studies elucidated the C-terminus of the CGRP-receptor. Staddon's work also sheds light on the genetic underpinnings of psychiatric disorders, with findings linking the dysbindin gene to bipolar affective disorder and the high-activity val allele of the catechol-O-methyltransferase gene to cognitive deterioration in psychosis. Furthermore, research associated dopamine D3 receptor gene polymorphisms with schizophrenia in an isolated population, highlighting the complexity of this complex disorder.